Maternal platelet antibody levels in neonatal isoimmune thrombocytopenia.
نویسندگان
چکیده
A case of neonatal isoimmune thrombocytopenia (NIT) is described in which maternal platelet antibody levels decreased during the course of pregnancy. It is suggested that if this disorder is clinically suspected, maternal serum should be assessed for anti-platelet specificity using immunoblot analysis.
منابع مشابه
A prospective study of maternal anti-HPA 1a antibody level as a potential predictor of alloimmune thrombocytopenia in the newborn.
BACKGROUND Neonatal alloimmune thrombocytopenia is most commonly due to transplacental passage of maternal anti-HPA 1a antibodies. A prospective study was carried out to evaluate the pattern and quantity of maternal anti-HPA 1a antibodies in order to predict the level of thrombocytopenia in the neonates. DESIGN AND METHODS A monoclonal antibody immobilization of platelet antigen assay was use...
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SYMPTOMATI C thrombocytopenia occurring in the neonatal period is a potentially serious disorder resulting in death in approximately 14 per cent of reported cases.1'2 Some affected infants are born of mothers who have, or have had, idiopathic thrombocytopenic purpura (ITP) In these cases it is assumed that a thrombocytopenic factor is transmitted to the fetus across the placenta, but the nature...
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متن کاملTrue risk of fetal/neonatal alloimmune thrombocytopenia in subsequent pregnancies: a prospective observational follow-up study.
OBJECTIVES To assess neonatal platelet counts by comparing alloimmunised pregnancies from a Norwegian screening and intervention study with subsequent pregnancies from the same women. DESIGN Prospective observational follow-up study. SETTING A university hospital. POPULATION HPA-1a immunised women from a large Norwegian screening study that gave birth to one or more children after the scr...
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BACKGROUND Different therapeutic approaches have been used in fetal-neonatal alloimmune thrombocytopenia, but many centers administer immunoglobulin G infusions to the pregnant woman. We studied the effect of maternal antenatal immunoglobulin infusions on fetal platelet counts in pregnancies with fetal alloimmune thrombocytopenia. DESIGN AND METHODS We retrospectively analyzed the clinical co...
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ورودعنوان ژورنال:
- Annals of clinical and laboratory science
دوره 20 3 شماره
صفحات -
تاریخ انتشار 1990